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POSTDOCTORANTE
Posdoctoral fellow
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anne abot

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​00 33 (0)5 62 74 45 21
EQUIPE 3 : INTERACTIONS NEURO-IMMUNES ​INTESTINALES
TEAM 3 : INTESTINAL NEURO-IMMUNE INTERACTIONS

Mini CV

2013: PhD « Role of oestrogen et nouvelles approches thérapeutiques” University Toulouse III
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expertise

  • Animal surgery (ig, iv, icv)
  • Real-time measurement of reactive oxygen and nitrogen species
  • Intestinal contraction (telemetry, isotonic)
  • Molecular and cellular biology (Western Blot, qPCR,…)
  • Glucose metabolism (OGTT, ITT, clamp)
  • Primary culture of enteric neurons

Recherche/projet  research/project

Identify new bioactive molecules modulating the “gut-brain-peripheral axis” to improve glucose metabolism disorders
Evaluate the therapeutic potential of modulating the "gut-to-brain" axis activity to treat metabolic disease including Type 2 diabetes.  

Production scientifique scientific production 

  • Glucosensing in the gastrointestinal tract: Impact on glucose metabolism, Fournel A, Marlin A, Abot A, Pasquio C, Cirillo C, Cani PD, Knauf C., Am J Physiol Gastrointest Liver Physiol. 2016 Mar 3:ajpgi.00015.2016.
  • The uterine and vascular actions of Estetrol delineate a distinctive profile of Estrogen Receptor α modulation, uncoupling nuclear and membrane activation. Abot A, Fontaine C, Solinhac R, Drougard A, Fabre A, Rajan S, Laine M, Buscato M, Milon A, Henrion D, Mestdagt M, Raymond-Letron I, Knauf C, Gourdy P, Flouriot G, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL,  Foidart JM and Arnal JF, EMBO Mol Med. 2014 Sep 11;6(10):1328-46.
  • Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions. Adlanmerini M, Solinhac R, Abot A, Fabre A, Raymond-Letron I, Guihot AL, Boudou F, Sautier L, Vessières E, Kim SH, Lière P, Fontaine C, Krust A, Chambon P, Katzenellenbogen JA, Gourdy P, Shaul PW, Henrion D, Arnal JF, Lenfant F, Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):E283-90.
  • Association between adiponectin and cartilage degradation in human osteoarthritis. Francin PJ, Abot A, Guillaume C, Moulin D, Bianchi A, Gegout-Pottie P, Jouzeau JY, Mainard D, Presle N. Osteoarthritis Cartilage. 2014 Mar;22(3):519-26