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  • HOME
  • About
    • DIRECTION
  • Research
    • teams >
      • TEAM 1 PATHOPHYSIOLOGY OF THE INTESTINAL EPITHELIUM
      • ​TEAM 2 PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA
      • TEAM 3 INTESTINAL NEURO-IMMUNE INTERACTIONS
      • TEAM 4 IRON METABOLISM: FROM REGULATION TO THERAPY
      • TEAM 5 ERYTHROFERRONE AND IRON HOMEOSTASIS
      • TEAM6 ENVIRONMENT & INTESTINAL EPITHELIUM INTERACTIONS -EINSTEIN-
    • Core facilities >
      • DIGESTIVE MODELS
      • ORGANOIDS
    • Publications >
      • Help for scientific writing
  • EDUCATION
    • MASTER
    • THESIS >
      • THESIS TOPICS PROPOSALS
      • THESIS DEFENSES
  • JOBS
    • JOB OFFERS >
      • GROUP LEADER
    • PREPARATION FOR COMPETITION
  • Events
    • IRSD Retreat >
      • 2016
      • 2017
    • Progress Reports
    • IRSD seminars
  • SERVICES
  • Highlights
  • Pictures
  • Contacts
    • Contact IRSD
    • Contact team
    • Contact Core Facilities
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CHERCHEUR INSERM
CR1
​INSERM

Permanent researcher

Celine  DEraison 

contact

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00 33 (0)5 62 74 45 04
EQUIPE 1 : PATHOPHYSIOLOGIE DE L’EPITHELIUM INTESTINAL
TEAM 1 : PATHOPHYSIOLOGY OF THE INTESTINAL EPITHELIUM
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Mini CV

  • 2015- Associate Member, Inflammation Research Network, Uni. of Calgary
  • 2014-2015: Visiting professor in Prof. McKay team, department of Physiology & Pharmacology, University of Calgary, Canada. “The role of elastase/elastase inhibitor balance in dialog between intestinal epithelial cells and macrophages in inflammatory bowel diseases context”
  • 2014: Capacitation as Research Director, Faculty of Sciences, Toulouse University, France
  • 2009-2010: INSERM tenured research scientist (CR1), Head of the group « Physiopathology of Netherton syndrome » in the team of Pr A. Hovnanian, INSERM U563, Toulouse, France
  • 2006-2009: Assistant Professor, Deciphering the role of epidermal serine proteases in Netherton syndrome disease and identify therapeutic targets, in Prof A. Hovnanian’s team, INSERM U563, Toulouse, France
  • 2002-2006: Post-doctoral fellow, Characterisation of LEKTI activity towards epidermal proteinases. Advisor: Pr A. Hovnanian, INSERM U563 Toulouse, France
  • 2002: PhD, Characterisation of new protease inhibitors to develop aphid resistant transgenic plants. Advisors: Dr L. Jouanin, INRA Versaillles, France and Dr Y. Rahbé, INRA Lyon, France

expertise

  • ​Customize and Development of mouse models (colitis murine models (DSS, TNBS), genetically modified mice (IL10 KO, PAR2 KO))
  • Molecular biology (nucleic acid extraction and analysis, cloning and directed mutagenesis, Custom and production of lentivirus).
  • Biochemistry (Enzymology, quantification of enzymatic activity in vitro and on biopsy, Immunolocalisation, optical and confocal microscopy, electron microscopy, quantitative analysis of images, Western blotting, Immunoprecipitation, purification, Heterologous expression of protein and purification).
  • Primary and cell lines culture.

Recherche/projet  research/project

Proteases from epithelial cells, mediators of inflammation in IBD
​
Tissue homeostasis is disrupted in a number of chronic diseases. In particular, proteolytic homeostasis which plays major roles in tissue remodelling and in digestive organ functions, is disrupted in inflammatory bowel disease (IBD). Therefore, a better knowledge of the actors involved in proteolytic homeostasis is a major step towards disease comprehension and diagnostic. Two types of molecules regulate proteolytic homeostasis: proteases and protease inhibitors, defining the proteolytic status of the tissues. The characterization of the proteases hyperactive in the inflamed gut, their substrates, and the consequences of their increased activity will advance our knowledge of the biological cascades initiated by protease dysregulation in IBD.  We expect of our analysis of protease hyperactivity to identify control points in the mechanisms of disease that could be addressed by the development of specific inhibitors, as the basis of novel therapeutic approaches for IBD.

Production scientifique scientific production 

  • Basso L, Boué J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G. Endogenous analgesia mediated by CD4(+) T lymphocytes is dependent on enkephalins in mice. J Neuroinflammation. 2016 Jun 1;13(1):132
  • Bermudez-Humaran, L & Motta, JP, Aubry C,  Kharrat P. Rous-Martin L, Sallenave JM, Deraison C, Vergnolle N, Langella P. Serine protease inhibitors protect better than IL-10 and TGF-beta anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci, Microbial Cell Factories, 2015 Dec;14(1):198.
  • Bermúdez-Humarán LG, Aubry C, Motta JP, Deraison C, Steidler L, Vergnolle N, Chatel JM, Langella P. Engineering lactococci and lactobacilli for human health. Curr Opin Microbiol. 2013 Jul 11. S1369-5274(13)00076-3
  • Motta JP & Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N. Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis. Sci Transl Med. 2012 31;4(158) *Joint First Authors

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INSERM IRSD U1220 , CHU PURPAN PLACE DU DOCTEUR BAYLAC, 
​CS 60039 31024, TOULOUSE CEDEX 3  
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