POST DOC
INRA

jean-paul motta

contact


00 33 (0)5 62 74 45 56​
EQUIPE 2 : PATHOGÉNIE ET COMMENSALISME DES ENTEROBACTÉRIES
TEAM 2 : PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA

Mini CV

  • present: INRA AgreenSkills+ postdoc fellow,
  • 2013-2018: Postdoc Killam Laureate (2013-2015)/ University of Calgary Eye's High (2013-2015) / Bourse CIHR-CAG Research Fellow (2013) / Alberta-Inovates Health-Solutions (2015-2018).
(1) Department of Biological Sciences, Faculty of Sciences, (2) Department of Pharmacology and Physiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

  • 2009-2012: PhD candidate, University Paul Sabatier of Toulouse, France.
Centre de Physiopathologie de l'Hopital Toulouse Purpan (CPTP), INSERM U1043, Toulouse
  • 2008-2009: Master II of Research, University Paul Sabatier of Toulouse, France Centre of Physiopathology of Toulouse Hospital Purpan (CPTP), INSERM U1043, Toulouse 

personal interest

Bacterial biofilms in the context of intestinal infectious and inflammatory diseases

key words

Biofilms and Intestinal Microbiota, Inflammatory Bowel Diseases, Inflammation, Intestinal Epithelial Cells, Proteases/Antiproteases , Enteropathogenic Infections

Recherche/projet  research/project

Enterobacterial infections and dysbyosis in metabolic diseases, gut inflammation and cancer

Production scientifique scientific production 

selected articles
  • Motta JP., Allain T, L. G-H, Groves R, T. F, H. R, Beck P, Lewis I, Wallace JL, and Buret A. "Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease" (2018) Inflammatory Bowel Diseases accepted 02/2018
  • Motta, JP., K. L. Flannigan, T. A. Agbor, J. K. Beatty, R. W. Blackler, M. L. Workentine, G. J. Da Silva, R. Wang, A. G. Buret and J. L. Wallace (2015). "Hydrogen Sulfide Protects from Colitis and Restores Intestinal Microbiota Biofilm and Mucus Production." Inflammatory Bowel Diseases 21(5): 1006-1017.
  • Bermudez-Humaran, L. G.*, JP. Motta*, C. Aubry, P. Kharrat, L. Rous-Martin, J. M. Sallenave, C. Deraison,
  • N. Vergnolle* and P. Langella* (2015). "Serine protease inhibitors protect better than IL-10 and TGF-beta anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci." Microbial Cell Factories 14(26). doi:10.1186/s12934-015-0198-4

  • Motta, JP.*, L. G. Bermudez-Humaran*, C. Deraison, L. Martin, C. Rolland, P. Rousset, J. Boue, G. Dietrich, K. Chapman, P. Kharrat, J. P. Vinel, L. Alric, E. Mas, J. M. Sallenave, P. Langella* and N. Vergnolle* (2012). "Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis." Science Translational Medicine 4(158).
  • Motta, JP.*, L. Magne*, D. Descamps, C. Rolland, C. Squarzoni-Dale, P. Rousset, L. Martin, N. Cenac, V. Balloy, M. Huerre, L. F. Frohlich, D. Jenne, J. Wartelle, A. Belaaouaj, E. Mas, J. P. Vinel, L. Alric, M. Chignard, N. Vergnolle* and J. M. Sallenave* (2011). "Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis." Gastroenterology 140(4): 1272-1282.
  • Motta, JP., L. Martin and N. Vergnolle (2011). Proteases/Antiproteases in Inflammatory Bowel Diseases. Proteases and Their Receptors in Inflammation., Springer Basel: 173-215.