léon kautz |
CONTACTS
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TEAM 5 : ERYTHROFERRONE AND IRON METABOLISM
STARTING ERC GRANT |
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Mini CV2009 : Doctorat physiopathologie, Université Paul Sabatier Toulouse
2010-2015 : postdoctorant, Université de Californie, Los Angeles 2016: CR1 Inserm |
expertiseExpertise in molecular biology
Use of multiple murine models |
RECHERCHE/PROJET RESEARCH/PROJECT
Role of the erythroid hormone erythroferrone in the regulation of iron homeostasis
The erythroid hormone erythroferrone (ERFE) plays a major role in iron metabolism. It acts to facilitate the recovery from anemia (consecutive to hemorrage, inflammation, malaria…) but it also causes iron overload in thalassemia. ERFE is a promising target for the treatment of different forms of anemia. However, nothing is known about the ERFE mechanism or its potential contribution to different pathologies, which is the subject of my research program.
The erythroid hormone erythroferrone (ERFE) plays a major role in iron metabolism. It acts to facilitate the recovery from anemia (consecutive to hemorrage, inflammation, malaria…) but it also causes iron overload in thalassemia. ERFE is a promising target for the treatment of different forms of anemia. However, nothing is known about the ERFE mechanism or its potential contribution to different pathologies, which is the subject of my research program.
PRODUCTION SCIENTIFIQUE SCIENTIFIC PRODUCTION
1. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat.Genet. 2014;46(7):678-684.
2. Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014;124(16):2569-2574
3. Kautz L. [Erythroferrone, an erythroid regulator of iron metabolism]. Med.Sci.(Paris). 2014;30(10):834-836.
4. Kautz L, Nemeth E. Molecular liaisons between erythropoiesis and iron metabolism. Blood. 2014;124(4):479-482.
5. Kautz L, Jung G, Du X, et al. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia. Blood. 2015;126(17):2031-2037.
2. Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014;124(16):2569-2574
3. Kautz L. [Erythroferrone, an erythroid regulator of iron metabolism]. Med.Sci.(Paris). 2014;30(10):834-836.
4. Kautz L, Nemeth E. Molecular liaisons between erythropoiesis and iron metabolism. Blood. 2014;124(4):479-482.
5. Kautz L, Jung G, Du X, et al. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia. Blood. 2015;126(17):2031-2037.
