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  • HOME
  • About
    • DIRECTION
  • Research
    • teams >
      • TEAM 1 PATHOPHYSIOLOGY OF THE INTESTINAL EPITHELIUM
      • ​TEAM 2 PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA
      • TEAM 3 INTESTINAL NEURO-IMMUNE INTERACTIONS
      • TEAM 4 GENETICS AND REGULATION OF IRON METABOLISM
      • TEAM 5 ERYTHROFERRONE AND IRON HOMEOSTASIS
      • RESEARCH GROUP ENVIRONMENT & INTESTINAL EPITHELIUM INTERACTIONS -EINSTEIN-
    • Core facilities >
      • DIGESTIVE MODELS
      • ORGANOIDS
    • Publications
  • EDUCATION
    • MASTER
    • THESIS >
      • THESIS TOPICS PROPOSALS
      • THESIS DEFENSES
  • JOBS
    • JOB OFFERS >
      • GROUP LEADER
    • PREPARATION FOR COMPETITION
  • Events
    • IRSD Retreat >
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​

CHERCHEUR INSERM
​CR1
​

Permanent researcher

léon kautz

CONTACTS

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00 33 (0)5 62 74 61 38
TEAM 5 : ERYTHROFERRONE AND IRON METABOLISM
​STARTING ERC GRANT

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Mini CV

2009 : Doctorat physiopathologie, Université Paul Sabatier Toulouse
2010-2015 : postdoctorant, Université de Californie, Los Angeles
2016: CR1 Inserm

expertise

Expertise in molecular biology
Use of multiple murine models
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RECHERCHE/PROJET  RESEARCH/PROJECT

Role of the erythroid hormone erythroferrone in the regulation of iron homeostasis

The erythroid hormone erythroferrone (ERFE) plays a major role in iron metabolism. It acts to facilitate the recovery from anemia (consecutive to hemorrage, inflammation, malaria…) but it also causes iron overload in thalassemia. ERFE is a promising target for the treatment of different forms of anemia. However, nothing is known about the ERFE mechanism or its potential contribution to different pathologies, which is the subject of my research program.

PRODUCTION SCIENTIFIQUE SCIENTIFIC PRODUCTION 

1.        Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat.Genet. 2014;46(7):678-684.
2.        Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014;124(16):2569-2574
3.        Kautz L. [Erythroferrone, an erythroid regulator of iron metabolism]. Med.Sci.(Paris). 2014;30(10):834-836.
4.        Kautz L, Nemeth E. Molecular liaisons between erythropoiesis and iron metabolism. Blood. 2014;124(4):479-482.
5.        Kautz L, Jung G, Du X, et al. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia. Blood. 2015;126(17):2031-2037.

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