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  • HOME
  • About
    • DIRECTION
  • Research
    • teams >
      • TEAM 1 PATHOPHYSIOLOGY OF THE INTESTINAL EPITHELIUM
      • ​TEAM 2 PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA
      • TEAM 3 INTESTINAL NEURO-IMMUNE INTERACTIONS
      • TEAM 4 IRON METABOLISM: FROM REGULATION TO THERAPY
      • TEAM 5 ERYTHROFERRONE AND IRON HOMEOSTASIS
      • TEAM6 ENVIRONMENT & INTESTINAL EPITHELIUM INTERACTIONS -EINSTEIN-
    • Core facilities >
      • DIGESTIVE MODELS
      • ORGANOIDS
    • Publications >
      • Help for scientific writing
  • EDUCATION
    • MASTER
    • THESIS >
      • THESIS TOPICS PROPOSALS
      • THESIS DEFENSES
  • JOBS
    • JOB OFFERS >
      • GROUP LEADER
    • PREPARATION FOR COMPETITION
  • Events
    • IRSD Retreat >
      • 2016
      • 2017
    • Progress Reports
    • IRSD seminars
  • SERVICES
  • Highlights
  • Pictures
  • Contacts
    • Contact IRSD
    • Contact team
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Ingénieur de valorisation
​

Valorization engineer

patricia martin

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​

EQUIPE 2 : PATHOGÉNIE ET COMMENSALISME DES ENTEROBACTÉRIES
TEAM 2 : PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA
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Mini CV

  • Depuis février 2019       Toulouse Tech Transfer
           Ingenieur de valorisation
            Projet VacVes, tilisation des OMV comme plateforme vaccinale

  • Janvier 2018-Janvier 2019       VibioSphen
           Directrice scientifique en charge R&D
           Recherche d'alternatives aux antibiotiques (vaccins, probiotiques)

  • Février 2011-décembre 2017                               Université Toulouse, Inserm, INRA, France
    Centre de physiopathologie Toulouse-Purpan/IRSD
    Equipe Commensalisme et pathogénie des Entérobactéries
    Thème : Interaction hôte-pathogène, le colibacille (Escherichia coli)
    Direction : Pr. Eric OSWALD.

  • Décembre 2004-Octobre 2009             Université Paris Descartes, Inserm, France
    Hôpital Necker Enfants Malades
    Unité Pathogénie des maladies infectieuses
    Thème : Interaction hôte-pathogène, le méningocoque (Neisseria meningitidis)
    Direction : Pr. Xavier NASSIF.

  • Janvier 2001-Octobre 2004     Université Oxford, Royaume-Uni
    Weatherall Institute of Molecular Medicine Department of paediatrics
    Thème : Variation de phase chez la bactérie pathogène Neisseria meningitidis
    Direction : Pr. E. Richard MOXON.

Recherche/projet  research/project

​Molecular bases of commensalism and pathogenesis of enterobacteria
Biosynthèse des facteurs de virulence chez les enterobactéries

Production scientifique scientific production 

24 articles, 2 patents:

Delphine Payros D, Ulrich Dobrindt U, Patricia Martin, Thomas Secher, Ana Paula Bracarense, Michèle Boury, Joelle Laffitte, Philippe Pinton, Eric Oswald and  Isabelle Oswald. The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota. MBio. 2017. 8(2) pii: e00007-17 (IF 6.4)

Sarah Tomkovich, Ye Yang, Kathryn Winglee, Josee Gauthier, Marcus Mühlbauer, Xiaolun Sun, Mansour Mohamadzadeh, Xiuli Liu, Patricia Martin, Gary P. Wang, Eric Oswald, Anthony A. Fodor, Christian Jobin. Locoregional effects of microbiota in a preclinical model of colon carcinogenesis. Cancer Research. 2017. 77(10):2620-2632 (IF 8.6)

Patricia Martin, Sophie Tronnet, Christophe Garcie, Eric Oswald. Interplay between siderophores and colibactin genotoxin in Escherichia coli. IUBMB Life. 2017. doi: 10.1002/iub.1612. (IF 2.6)

Sophie Tronnet, Christophe Garcie, Nadine Rehms, Ulrich Dobrindt, Eric Oswald, Patricia Martin. Iron homeostasis regulates the genotoxicity of Escherichia coli producing colibactin. Infect Immun. Infection and immunity. 2016. 84(12):3358-3368 (IF 3.7)
 
Christophe Garcie, Sophie Tronnet, Amélie Garénaux, A.J. McCarthy, A.O. Brachmann, Marie Pénary, Sébastien Houle, J-P. Nougayrède, Jorn Piel, P.W. Taylor, C.M. Dozois, Pierre Genevaux, Eris Oswald, Patricia Martin. The stress-responsive Hsp90 chaperone controls genotoxin and siderophore production by pathogenic Escherichia coli. Journal of Infectious Diseases. 2016. 214(6):916-24 (IF 6.0)
 
Patricia Martin*, Kazunori Murase*, Gaëlle Porcheron, Sebastien Houle, Emmanuelle Helloin, Marie Pénary, Jean-Philippe Nougayrède, Charles Dozois, Tetsuya Hayashi, Eric Oswald.  HlyF produced by extraintestinal pathogenic Escherichia coli is a virulence factor that regulates outer membrane vesicle biogenesis. Journal of Infectious Diseases. 2016. 213(5):856-65. *co-premier auteur. (IF 6.0)
 
Nadège Bossuet-Greif, Damien Dubois, Sophie Tronnet, Patricia Martin, Richard Bonnet, Eric Oswald, Jean-Philippe Nougayrède. Escherichia coli ClbS is a colibactin resistance protein.  Molecular Microbiology. 2016.99(5):897-908. (IF 4.4)
 
Alex J. McCarthy, Patricia Martin, Emilie Cloup, Richard Stabler, Eric Oswald, Peter W. Taylor. The genotoxin colibactin is a determinant of virulence in Escherichia coli K1 experimental neonatal systemic infection. 2015. Infection and Immunity 83(9):3704-11 (IF 3.7)
 
Aurélie Gineste, Patricia Martin, Eric Oswald, Hélène Coppin, Marie-Paule Roth, 2015 Evidence for IL-6/STAT3-independent induction of lipocalin-2 in the liver of mice infected with Escherichia coli, Hepathology doi: 10.1002/hep.27845. (IF 11.0)
 
Alexander O. Brachmann, Christophe Garcie,V. Wu, Patricia Martin, R. Ueoka, Eric Oswald, Jörn Piel, 2015. Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor. ChemComm 51(66):13138-41. (IF 6.8)
 
Ingrid Marcq, Patricia Martin, Delphine Payros, Gabriel Cuevas, Michèle Boury, Claude Watrin, Jean-Philippe Nougayrède, Maïwenn Olier, Eric Oswald, 2014. The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli. Journal of Infectious Diseases 210(2):285-94. (IF 6.0)
 
Patricia Martin, Ingrid Marcq, Giuseppe Magistro, Marie Penary, Christophe Garcie, Delphine Payros, Michèle Boury, Maïwenn Olier, Jean-Philippe Nougayrède, Marc Audebert, Christian Chalut, Sören Schubert, Eric Oswald, 2013 Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli. PLoS Pathogens 9(7):e1003437. (IF 7.6)
 
Anne Jamet, Daniel Euphrasie, Patricia Martin, Xavier Nassif, 2013. Identification of genes involved in Neisseria meningitidis colonization. Infection and Immunity 81(9):3375-81. (IF 3.7)
 
Anne Jamet, Eric Frapy, Marion Dupuis, Dominique Schneider, Xavier Nassif, Patricia Martin, 2012. A cell-contact-regulated operon is involved in genetic variability in Neisseria meningitidis. Research in Microbiology 163(3), 192-9. (IF 2.7)

Julia Chamot-Rooke, Guillain Mikaty, Christian Malosse, Magali Soyer, Patricia Martin, Guilhem Clary, Philippe Chafey, Luc Camoin, Xavier Nassif, Guillaume Duménil, 2011 Posttranslational modification of pili upon cell contact triggers N. meningitidis dissemination. Science 331(6018), 778-82. (IF 33.6)

Anne Jamet, Clotilde Rousseau, Jean-Benoît Monfort, Xavier Nassif, Patricia Martin, 2010 Identification of a novel transcriptional regulator involved in pilC1 regulation in Neisseria meningitidis. FEMS Microbiol Lett. 304(2), 140-147. (IF 2.1)
 
Anne Jamet, Clotilde Rousseau, Jean-Benoît Monfort, Eric Frapy, Xavier Nassif, Patricia Martin, 2009. A two-component system is required for colonization of host cells by meningococcus. Microbiology 155(7), 2288 – 2295. (IF 2.5)
 
Christopher D. Bayliss, J. Claire Hoe, Katherine Makepeace, Patricia Martin, Derek W. Hood, E. Richard Moxon, 2008 Neisseria meningitidis escape from the bactericidal activity of a monoclonal antibody is mediated by phase variation of lgtG and enhanced by a mutator phenotype. Infection and Immunity 76 (11), 5038-5048. (IF 3.7)
 
Patricia Martin*, Kazutoyo Yasukawa*, Colin R. Tinsley, Xavier Nassif, 2006. Pilus-mediated adhesion of Neisseria meningitidis is negatively controlled by the pilus-retraction machinery. Molecular Microbiology, 59 (2), 579-589. * co-premier auteur (IF 4.4)
 
Patricia Martin, Katherine Makepeace, Stuart A. Hill, Derek W. Hood, E. Richard Moxon, 2005. Microsatellite instability regulates transcription factor binding and gene expression. Proceedings of the National Academy of Sciences USA 102 (10), 3800-3804. (IF 9.7)
 
Patricia Martin, Li Sun, Derek W. Hood, E. Richard Moxon, 2004. Involvement of genes of genome maintenance in the regulation of phase variation frequencies in Neisseria meningitidis. MC58, Microbiology 150, 3001-3012. (IF 2.5)
 
Patricia Martin, Tamsin van de Ven, Nathalie Mouchel, Alex C. Jeffries, Derek W. Hood, E. Richard Moxon, 2003. Experimentally revised repertoire of putative contingency loci in Neisseria meningitidis strain MC58: evidence for a novel mechanism of phase variation. Molecular Microbiology 50 (1), 245-257. (IF 4.4)
 
 
Brevet
 
1°) Date de dépôt : 03/07/2013 ; Numéro de dépôt : EP13305943.6
Methods for the screening of substances that may be useful for the prevention and treatment of infections by enterobacteriaceae family
Inventeurs : Eric Oswald, Patricia Martin
 
 
2°) Date de dépôt : 07/04/2014 ; Numéro de dépôt : EP14305508.5
New method for producing outer membrane vesicles.
Inventeurs: Eric Oswald, Patricia Martin, Kazunori Murase

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