IRSD members have a unique opportunity to gather their expertise and to structure research task forces around their common interest: a better understanding of the digestive tract physiology. Our common mission is to conduct and support medical research and research training, and to disseminate new knowledge and practices in digestive health. 

OBJECTIVES

The scientific strategy of the institute as a whole will follow several axes. 
•Strengthen the existing research programs and favor the emergence of new research programs in digestive science
•Propose state-of-the-art training and teaching in the domain of digestive science
•Support internal and external collaborations
•Ensure core facilities functions and share competencies
•Foster translational research and basic science/clinical interactions
•Establish strong links with industrial partners and foster technology transfers

OUR EXPERTISES

IRSD expertise lies in the physiology and pathophysiology of the digestive tract, covering major functions of the intestine and the liver. More specifically, members of the IRSD have gained considerable expertise in nutrient (glucose, lipids, iron) absorption, liver metabolism, intestinal pathophysiology, microbiota physiology (composition, pathogenicity, commensalism) and host-microbes interactions, but also nutrient, immunological and nociceptive sensing functions of the intestine. 

Different pathologies are studied in IRSD. 

INTESTINAL PATHOLOGIES

• Inflammatory Bowel Diseases (IBD)
• Irritable Bowel Syndrome (IBS)
• Colorectal Cancer
• Infectious colitis
• Maladies Inflammatoires Chroniques de l’Intestin (MICI)
• Celiac Disease / Gluten hypersensitivity
• Adenomatous polyposis
• Newborn colics
• Intestinal infection
• Malabsorption

LIVER PATHOLOGIES

• Hemochromatosis
• Secondary iron overload 
• NASH

Metabolic diseases

Diabetes type 2
Glucose intolerance
Dyslipidemia
Obesity